Idiopathic Thrombocytopenic Purpura and Dysmegakaryocytopoiesis

Crit Rev Oncol Hematol. 2007 Nov;64(2):83-9. doi: 10.1016/j.critrevonc.2007.05.007. Epub 2007 Sep 27.

Abstract

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized with thrombocytopenia, primarily caused by platelet destruction. However, the studies of platelet kinetics show platelet turn over are normal or decreased, suggesting that reduced platelet production may lead to severity of ITP. We review recent research progress on abnormal cell events involved in megakaryocytopoiesis contributing to thrombocytopenia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Platelets / immunology
  • Cytokines / blood
  • Humans
  • Megakaryocytes / pathology*
  • Purpura, Thrombocytopenic, Idiopathic / blood
  • Purpura, Thrombocytopenic, Idiopathic / etiology*
  • Purpura, Thrombocytopenic, Idiopathic / immunology
  • Thrombocytopenia / blood
  • Thrombocytopenia / etiology
  • Thrombopoiesis*

Substances

  • Cytokines