c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain

Stem Cells. 2008 Jan;26(1):173-81. doi: 10.1634/stemcells.2007-0293. Epub 2007 Sep 27.


Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult Stem Cells / cytology*
  • Adult Stem Cells / metabolism
  • Animals
  • Brain / cytology*
  • Brain / embryology
  • Brain / metabolism
  • Cell Count
  • Cell Differentiation / physiology
  • Cell Proliferation
  • DNA-Binding Proteins / biosynthesis
  • Eye Proteins / biosynthesis
  • Gene Expression
  • Gene Expression Regulation
  • Genes, myb*
  • Homeodomain Proteins / biosynthesis
  • Immunohistochemistry
  • In Situ Hybridization
  • In Situ Nick-End Labeling
  • Mice
  • Microscopy, Electron, Scanning
  • Neurons / cytology*
  • Neurons / metabolism*
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors / biosynthesis
  • RNA, Messenger / analysis
  • Repressor Proteins / biosynthesis
  • Reverse Transcriptase Polymerase Chain Reaction
  • SOXB1 Transcription Factors
  • Trans-Activators / biosynthesis


  • DNA-Binding Proteins
  • Eye Proteins
  • Homeodomain Proteins
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors
  • Pax6 protein, mouse
  • RNA, Messenger
  • Repressor Proteins
  • SOXB1 Transcription Factors
  • Sox2 protein, mouse
  • Trans-Activators