Inferring cellular networks--a review

BMC Bioinformatics. 2007 Sep 27;8 Suppl 6(Suppl 6):S5. doi: 10.1186/1471-2105-8-S6-S5.


In this review we give an overview of computational and statistical methods to reconstruct cellular networks. Although this area of research is vast and fast developing, we show that most currently used methods can be organized by a few key concepts. The first part of the review deals with conditional independence models including Gaussian graphical models and Bayesian networks. The second part discusses probabilistic and graph-based methods for data from experimental interventions and perturbations.

Publication types

  • Review

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Gene Expression Profiling / methods*
  • Models, Biological*
  • Oligonucleotide Array Sequence Analysis / methods*
  • Protein Interaction Mapping / methods*
  • Proteome / metabolism*
  • Signal Transduction / physiology*


  • Proteome