Acute dyskinesia on starting methylphenidate after risperidone withdrawal

Pediatr Neurol. 2007 Oct;37(4):287-8. doi: 10.1016/j.pediatrneurol.2007.05.017.

Abstract

We report on acute and transient dyskinesia occurring within hours of taking modified-release methylphenidate (Concerta XL) in a stimulant-naïve 7-year-old boy who had recently stopped taking risperidone. We propose that the mechanism of this adverse drug reaction is likely to be an interaction between supersensitive dopamine receptors and acute exposure to an indirect dopamine agonist. Clinicians need to be aware of this potential side effect, and to use the combination of psychostimulants and neuroleptic drugs with caution.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antipsychotic Agents / administration & dosage*
  • Antipsychotic Agents / therapeutic use
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / adverse effects*
  • Central Nervous System Stimulants / therapeutic use
  • Child
  • Delayed-Action Preparations
  • Dopamine Agonists / administration & dosage
  • Dopamine Agonists / adverse effects*
  • Dopamine Agonists / therapeutic use
  • Drug Administration Schedule
  • Dyskinesia, Drug-Induced* / physiopathology
  • Humans
  • Male
  • Methylphenidate / administration & dosage
  • Methylphenidate / adverse effects*
  • Methylphenidate / therapeutic use
  • Receptors, Dopamine / drug effects
  • Retreatment
  • Risperidone / administration & dosage*
  • Risperidone / therapeutic use

Substances

  • Antipsychotic Agents
  • Central Nervous System Stimulants
  • Delayed-Action Preparations
  • Dopamine Agonists
  • Receptors, Dopamine
  • Methylphenidate
  • Risperidone