Pregnancy loss in pregnancies conceived after in vitro oocyte maturation, conventional in vitro fertilization, and intracytoplasmic sperm injection

Fertil Steril. 2008 Sep;90(3):546-50. doi: 10.1016/j.fertnstert.2007.06.107. Epub 2007 Sep 27.


Objective: To compare rates of pregnancy loss after oocyte maturation in vitro (IVM), after IVF, and after intracytoplasmic sperm injection (ICSI).

Design: Retrospective comparative study.

Setting: University tertiary-care center for infertility.

Patient(s): Women undergoing assisted reproductive technology in a single center.

Intervention(s): Oocyte maturation in vitro, IVF, or ICSI, as indicated.

Main outcome measure(s): Biochemical pregnancy, clinical miscarriage, ectopic pregnancy, and late fetal loss.

Result(s): There were 1,581 positive pregnancy tests (120 IVM, 849 IVF, and 612 ICSI). The biochemical pregnancy loss rate did not statistically significantly differ among the groups: 17.5% (21/120) after IVM, 17.0% (144/849) after IVF, and 18.0% (110/612) after ICSI. The clinical miscarriage rate after IVM was 25.3% (25/99), which was statistically significantly different compared with 15.7% (111/705) after IVF and 12.6% (63/502) after ICSI. However, the clinical miscarriage rates in women with polycystic ovary syndrome were statistically similar, at 24.5% (24/98) after IVM and 22.2% (18/81) after IVF. The ectopic pregnancy rates also were statistically similar: 1.0% (1/99) after IVM, 2.3% (16/705) after IVF, and 1.8% (9/502) after ICSI. The late fetal loss rates were similar as well: 1.0% (1/99) after IVM, 2.7% (19/705) after IVF, and 2.9% (14/502) after ICSI. There were no chromosomal abnormalities in the IVM group.

Conclusion(s): There is a higher rate of clinical miscarriage after IVM when compared with IVF and ICSI. This appears to be related to polycystic ovary syndrome rather than to the IVM procedure.

Publication types

  • Comparative Study

MeSH terms

  • Abortion, Spontaneous / epidemiology*
  • Adult
  • Female
  • Fertilization in Vitro / statistics & numerical data*
  • Humans
  • Incidence
  • Infertility / epidemiology*
  • Infertility / therapy*
  • Pregnancy
  • Quebec / epidemiology
  • Retrospective Studies
  • Risk Assessment / methods*
  • Risk Factors
  • Sperm Injections, Intracytoplasmic / statistics & numerical data*
  • Treatment Outcome