Intracellular trafficking of raft/caveolae domains: insights from integrin signaling

Semin Cell Dev Biol. 2007 Oct;18(5):627-37. doi: 10.1016/j.semcdb.2007.08.004. Epub 2007 Aug 19.


Cells have a complex system for delivering and compartmentalizing proteins and lipids in order to achieve spatio-temporal coordination of signaling. Rafts/caveolae are plasma membrane microdomains that regulate signaling pathways and processes such as cell migration, polarization and proliferation. Regulation of raft/caveolae trafficking involves multiple steps regulated by different proteins to ensure coordination of signaling cascades. The best studied raft-mediated endocytic route is controlled by caveolins. Recent data suggest integrin-mediated cell adhesion is a key regulator of caveolar endocytosis. In this review we examine the regulation of caveolar trafficking and the interplay between integrins, cell adhesion and caveolae internalization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Caveolae / physiology*
  • Cell Adhesion / physiology
  • Cytoskeleton / physiology
  • Exocytosis / physiology*
  • Humans
  • Integrins / physiology*
  • Membrane Microdomains / physiology*
  • Models, Immunological
  • Signal Transduction / physiology*


  • Integrins