Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction

Trends Neurosci. 2007 Oct;30(10):504-11. doi: 10.1016/j.tins.2007.08.001. Epub 2007 Sep 29.


Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Kisspeptins
  • Neurosecretory Systems / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*
  • Receptors, Kisspeptin-1
  • Reproduction / physiology*
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins / physiology*


  • KISS1 protein, human
  • KISS1R protein, human
  • Kisspeptins
  • Receptors, G-Protein-Coupled
  • Receptors, Kisspeptin-1
  • Tumor Suppressor Proteins