Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures

Neuroimage. 2008 Jan 1;39(1):238-47. doi: 10.1016/j.neuroimage.2007.05.063. Epub 2007 Aug 22.


The large amount of imaging data collected in several ongoing multi-center studies requires automated methods to delineate brain structures of interest. We have previously reported on using artificial neural networks (ANN) to define subcortical brain structures. Here we present several automated segmentation methods using multidimensional registration. A direct comparison between template, probability, artificial neural network (ANN) and support vector machine (SVM)-based automated segmentation methods is presented. Three metrics for each segmentation method are reported in the delineation of subcortical and cerebellar brain regions. Results show that the machine learning methods outperform the template and probability-based methods. Utilization of these automated segmentation methods may be as reliable as manual raters and require no rater intervention.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Algorithms
  • Artificial Intelligence*
  • Cerebellum / anatomy & histology*
  • Cerebral Cortex / anatomy & histology*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods
  • Magnetic Resonance Imaging / methods*
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*