[Association study of an (AC)n dinucleotide repeat and schizophrenia in Asian and European populations]

Yi Chuan. 2007 Oct;29(10):1207-13. doi: 10.1360/yc-007-1207.
[Article in Chinese]

Abstract

Linkage studies have suggested that chromosome 15q13-q14 may harbor a susceptibility locus for schizophrenia. In the current study, the association between a (AC)n dinucleotide repeat polymorphism at D15S118 and schizophrenia was investigated using three independent samples from the Han Chinese population and the Scotland population. In the population-based study, a significant difference was found between the allele frequency distributions in schizophrenia patients and control subjects in the Scottish samples (P = 0.04), but was not replicated in the Chinese samples. In a family-based study, no significant transmission disequilibrium from heterozygous parents to affected offspring was observed. Overall, our results did not support the hypothesis that the (AC)n dinucleotide repeat polymorphism plays a major role in schizophrenia susceptibility, at least in the Chinese population. Further studies are needed to elucidate its role in schizophrenia susceptibility in European population.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Asian Continental Ancestry Group / genetics*
  • China
  • Chromosomes, Human, Pair 15 / genetics
  • Dinucleotide Repeats / genetics*
  • European Continental Ancestry Group / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Male
  • Microsatellite Repeats / genetics
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Schizophrenia / ethnology
  • Schizophrenia / genetics*
  • Scotland
  • Young Adult