Sodium and asthma: something borrowed, something new?

Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1369-73. doi: 10.1152/ajplung.00379.2007. Epub 2007 Sep 28.


Some early studies have called attention to the potential contribution of sodium (both dietary and serum levels) in airway-related disease, although the picture was not entirely clear. Two recent developments may now allow a more careful consideration of this: first, the greatly improved understanding of the role of salt in hypertension (particularly the identification of subgroups of salt-sensitive individuals within the general population), and second, the recent discovery of the role of the Na(+)/Ca(2+) exchanger in smooth muscle function. Here, we first review those two developments and then apply them to airway smooth muscle and asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asthma / metabolism*
  • Homeostasis
  • Humans
  • Hypertension / physiopathology
  • Muscle Contraction
  • Muscle, Smooth / enzymology
  • Rats
  • Sodium / metabolism*
  • Sodium Chloride, Dietary / metabolism
  • Sodium-Potassium-Exchanging ATPase / metabolism


  • Sodium Chloride, Dietary
  • Sodium
  • Sodium-Potassium-Exchanging ATPase