Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population

Br J Psychiatry. 2007 Oct:191:355-6. doi: 10.1192/bjp.bp.106.031195.


Atendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to schizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year 1 followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Delusions / psychology*
  • Disease Progression
  • Humans
  • Neuropsychological Tests / standards
  • Noise
  • Predictive Value of Tests
  • Risk Factors
  • Schizophrenia / diagnosis*
  • Schizophrenia / drug therapy
  • Schizophrenic Psychology*
  • Speech Perception*