A gene expression bar code for microarray data

Nat Methods. 2007 Nov;4(11):911-3. doi: 10.1038/nmeth1102. Epub 2007 Sep 30.


The ability to measure genome-wide expression holds great promise for characterizing cells and distinguishing diseased from normal tissues. Thus far, microarray technology has been useful only for measuring relative expression between two or more samples, which has handicapped its ability to classify tissue types. Here we present a method that can successfully predict tissue type based on data from a single hybridization. A preliminary web-tool is available online (http://rafalab.jhsph.edu/barcode/).

MeSH terms

  • Algorithms
  • Animals
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / genetics
  • Computational Biology / methods
  • Databases, Genetic
  • Electronic Data Processing / methods*
  • Female
  • Gene Expression Profiling / methods*
  • Gene Expression Profiling / statistics & numerical data
  • Genome / genetics*
  • Humans
  • Internet
  • Mice
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Array Sequence Analysis / statistics & numerical data
  • Prognosis