Genetics of aging in Caenorhabditis elegans

doi:10.1371/journal.pgen.0030129

Review

. 2007 Sep;3(9):1565-71.

doi: 10.1371/journal.pgen.0030129.

Genetics of aging in Caenorhabditis elegans

Adam Antebi¹

Affiliations

PMID: 17907808
PMCID: PMC1994694
DOI: 10.1371/journal.pgen.0030129

Review

Genetics of aging in Caenorhabditis elegans

Adam Antebi. PLoS Genet. 2007 Sep.

. 2007 Sep;3(9):1565-71.

doi: 10.1371/journal.pgen.0030129.

Author

Adam Antebi¹

Affiliation

¹ Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. aantebi@bcm.edu

PMID: 17907808
PMCID: PMC1994694
DOI: 10.1371/journal.pgen.0030129

Abstract

A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen.

PubMed Disclaimer

Conflict of interest statement

Competing interests. The author has declared that no competing interests exist.

Figures

**Figure 1. A Model for Insulin/IGF-1 Signal Transduction, Showing Associated Kinase Inputs and Nuclear Factors (See Text)**

See this image and copyright information in PMC

Cited by

Systems biology in aging: linking the old and the young.
Hou L, Huang J, Green CD, Boyd-Kirkup J, Zhang W, Yu X, Gong W, Zhou B, Han JD. Hou L, et al. Curr Genomics. 2012 Nov;13(7):558-65. doi: 10.2174/138920212803251418. Curr Genomics. 2012. PMID: 23633915 Free PMC article.
MicroRNAs and the genetic network in aging.
Inukai S, Slack F. Inukai S, et al. J Mol Biol. 2013 Oct 9;425(19):3601-8. doi: 10.1016/j.jmb.2013.01.023. Epub 2013 Jan 23. J Mol Biol. 2013. PMID: 23353823 Free PMC article. Review.
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
Heimbucher T, Liu Z, Bossard C, McCloskey R, Carrano AC, Riedel CG, Tanasa B, Klammt C, Fonslow BR, Riera CE, Lillemeier BF, Kemphues K, Yates JR 3rd, O'Shea C, Hunter T, Dillin A. Heimbucher T, et al. Cell Metab. 2015 Jul 7;22(1):151-63. doi: 10.1016/j.cmet.2015.06.002. Cell Metab. 2015. PMID: 26154057 Free PMC article.
Insulin/IGF1 signaling inhibits age-dependent axon regeneration.
Byrne AB, Walradt T, Gardner KE, Hubbert A, Reinke V, Hammarlund M. Byrne AB, et al. Neuron. 2014 Feb 5;81(3):561-73. doi: 10.1016/j.neuron.2013.11.019. Epub 2014 Jan 16. Neuron. 2014. PMID: 24440228 Free PMC article.
Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism.
Albani D, Batelli S, Polito L, Prato F, Pesaresi M, Gajo GB, De Angeli S, Zanardo A, Galimberti D, Scarpini E, Gallucci M, Forloni G. Albani D, et al. Age (Dordr). 2009 Jun;31(2):155-62. doi: 10.1007/s11357-009-9092-5. Epub 2009 Apr 18. Age (Dordr). 2009. PMID: 19377912 Free PMC article.

See all "Cited by" articles

References

1. Friedman DB, Johnson TE. A mutation in the age-1 gene in C. elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988;118:75–86. - PMC - PubMed
1. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461–464. - PubMed
1. Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in C. elegans. Nature. 1996;382:536–539. - PubMed
1. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science. 1997;277:942–946. - PubMed
1. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997;389:994–999. - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- MedlinePlus Health Information

[1] Friedman DB, Johnson TE. A mutation in the age-1 gene in C. elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988;118:75–86. - PMC - PubMed

[2] Friedman DB, Johnson TE. A mutation in the age-1 gene in C. elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988;118:75–86. - PMC - PubMed

[3] Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461–464. - PubMed

[4] Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461–464. - PubMed

[5] Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in C. elegans. Nature. 1996;382:536–539. - PubMed

[6] Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in C. elegans. Nature. 1996;382:536–539. - PubMed

[7] Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science. 1997;277:942–946. - PubMed

[8] Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science. 1997;277:942–946. - PubMed

[9] Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997;389:994–999. - PubMed

[10] Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997;389:994–999. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Genetics of aging in Caenorhabditis elegans

Affiliation

Genetics of aging in Caenorhabditis elegans

Author

Affiliation

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical