The use of statins and lung function in current and former smokers

Chest. 2007 Dec;132(6):1764-71. doi: 10.1378/chest.07-0298. Epub 2007 Oct 1.


Background: Smokers are affected by a variety of inflammatory diseases, including COPD. Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors, are used for their lipid-lowering characteristics but also appear to have antiinflammatory and immunomodulatory activities. We assessed their ability to preserve lung function in current and former smokers.

Methods: All smokers and ex-smokers seen at the Oklahoma City VA hospital in 2005 with abnormal baseline spirometry findings and two or more pulmonary function tests done 6 months apart were classified into obstructive and restrictive groups based on the initial PFT result. Statin use, annual decline in FEV(1) and FVC, and need for respiratory-related urgent care (emergency department or inpatient) were compared.

Results: Approximately one half, 215 of 418 patients, were receiving a statin. Compared to the control group, statin users had a lower decline in FEV(1) (- 0.005 +/- 0.20 L/yr vs 0.085 +/- 0.17 L/yr, p < 0.0001) and FVC (- 0.046 +/- 0.45 L/yr vs 0.135 +/- 0.32 L/yr, p < 0.0001) [mean +/- SD]. This difference remained significant irrespective of whether the patient had obstructive (n = 319), or restrictive (n = 99) disease, and regardless of whether the patient continued or stopped smoking. In patients with an obstructive spirometry finding, we found a lower incidence of respiratory-related urgent care in favor of the statin group (0.12 +/- 0.29 patient-years vs 0.19 +/- 0.32/patient-years; p = 0.02).

Conclusion: In smokers and former smokers, statins are associated with a slower decline in pulmonary function, independent of the underlying lung disease.

Clinical implication: Prospective, randomized trials are needed to study the effect of statins on lung function.

MeSH terms

  • Aged
  • Female
  • Forced Expiratory Volume / drug effects*
  • Forced Expiratory Volume / physiology
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Lung Diseases, Obstructive / drug therapy
  • Lung Diseases, Obstructive / physiopathology*
  • Male
  • Middle Aged
  • Regression Analysis
  • Respiratory Function Tests
  • Retrospective Studies
  • Smoking / physiopathology*
  • Vital Capacity / drug effects*
  • Vital Capacity / physiology


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors