Histone lysine demethylases: emerging roles in development, physiology and disease

Nat Rev Genet. 2007 Nov;8(11):829-33. doi: 10.1038/nrg2218.


The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Regulation, Developmental / physiology*
  • Histone-Lysine N-Methyltransferase / genetics
  • Histone-Lysine N-Methyltransferase / physiology*
  • Histones / genetics
  • Histones / metabolism*
  • Humans
  • Lysine / genetics
  • Lysine / metabolism*
  • Methylation
  • Molecular Sequence Data
  • Neoplasms / enzymology*
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Nervous System Diseases / enzymology*
  • Nervous System Diseases / genetics
  • Nervous System Diseases / physiopathology


  • Histones
  • Histone-Lysine N-Methyltransferase
  • Lysine