Analysis of Y-chromosomal SNP Haplogroups and STR Haplotypes in an Algerian Population Sample

Int J Legal Med. 2008 May;122(3):251-5. doi: 10.1007/s00414-007-0203-5. Epub 2007 Oct 2.

Abstract

The distribution of Y-chromosomal single nucleotide polymorphism (SNP) haplogroups and short tandem repeat (STR) haplotypes was determined in a sample of 102 unrelated men of Arab origin from northwestern Algeria (Oran area). A total of nine different haplogroups were identified by a panel of 22 binary markers. The most common haplogroups observed in the Algerian population were E3b2 (45.1%) and J1 (22.5%). Y-STR typing by a 17-loci multiplex system allowed 93 haplotypes to be defined (88 were unique). Striking differences in the allele distribution and gene diversity of Y-STR markers between haplogroups could be found. In particular, intermediate alleles at locus DYS458 specifically characterized the haplotypes of individuals carrying haplogroup J1. All the intermediate alleles shared a common repeat sequence structure, supporting the hypothesis that the variant originated from a single mutational event.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algeria
  • Arabs / genetics
  • Chromosomes, Human, Y*
  • DNA Fingerprinting
  • Gene Frequency
  • Genetics, Population*
  • Haplotypes*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Tandem Repeat Sequences*