[Diagnostic accuracy of FP-CIT SPECT in patients with parkinsonism]

Rev Esp Med Nucl. 2007 Sep-Oct;26(5):277-85.
[Article in Spanish]


Objective: To determine the diagnostic accuracy of FP-CIT SPECT in entities with and without presynaptic involvement of the nigral-striatal dopaminergic pathway in a large group of patients with movement disorders, evaluating the usefulness of quantitative analysis.

Materials and methods: A group of 183 consecutive patients clinically diagnosed as either having or not having degenerative Parkinsonism. These results were then contrasted with those of FP-CIT SPECT to determine the diagnostic accuracy of the procedure. The specific binding index was evaluated with ROC curves.

Results: FP-CIT SPECT was highly accurate in the diagnosis of neurodegenerative Parkinsonism (sensitivity: 95 %, specificity: 90 %). Most of the false positive results arose in patients with vascular Parkinsonism and the false negative results in patients with Parkinson disease. ROC curve analysis of semiquantitative evaluation had a sensitivity of 83 % and specificity of 82 % with an optimal cut-off of 1.44. The area under the curve was not significantly different between patients </= 60 and > 60 years (0.899 vs 0.884) of age.

Conclusions: FP-CIT SPECT has a high degree of diagnostic accuracy for striatal dopaminergic involvement. No significant changes in diagnostic accuracy were seen with respect to patient age.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain / diagnostic imaging*
  • Diagnosis, Differential
  • Female
  • Humans
  • Iodine Radioisotopes*
  • Male
  • Middle Aged
  • Parkinsonian Disorders / diagnostic imaging*
  • Reproducibility of Results
  • Tomography, Emission-Computed, Single-Photon*
  • Tropanes*


  • Iodine Radioisotopes
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane