ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege

Ann N Y Acad Sci. 2007 Dec;1120:144-51. doi: 10.1196/annals.1411.005. Epub 2007 Oct 2.


The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as the targeted deletion of the Etv5 gene in mice (Etv5(-/-)) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild-type (WT) and Etv5(-/-) testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5(-/-) recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5(-/-) mouse.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood-Testis Barrier / immunology
  • Blood-Testis Barrier / physiology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Immunity, Innate / genetics*
  • Male
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Spermatogenesis / genetics*
  • Testis / immunology*
  • Tight Junctions / immunology
  • Tight Junctions / physiology
  • Transcription Factors / genetics
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • Etv5 protein, mouse
  • Transcription Factors