Using an asymmetric color matching technique, we measured the perceived changes that occur in the saturation and hue of colored stimuli at different eccentricities within the central 25 degrees of the human retina in nine color-normal subjects. A cone-opponent-based vector model was used to compute the activity of the L-M and S-(L+M) channels. The results show that a large proportion of the shifts in saturation and hue that occur with increasing retinal eccentricity are mirrored by decreased activity of the L-M channel. In comparison, the contribution of the S cone-opponent system undergoes relatively little change within the central 20 degrees . In addition, we also found that changes in saturation and hue are different from each other in terms of their variation across color space and their variation with stimulus size. Our findings suggest that perceived shifts in saturation and hue are mediated largely via the reduction in activation of the L-M cone-opponent channel but that saturation and hue might be subject to different retinal and/or cortical influences that contribute to their differing size dependencies in the peripheral retina.