Peroxisomal Dynamics

Trends Cell Biol. 2007 Oct;17(10):474-84. doi: 10.1016/j.tcb.2007.06.009.

Abstract

Peroxisomes are a dynamic compartment in almost all eukaryotic cells and have diverse metabolic roles in response to environmental changes and cellular demands. The accompanying changes in enzyme content or abundance of peroxisomes are accomplished by dynamically operating membrane- and matrix-protein transport machineries. This review discusses recent progress in understanding peroxisomal proliferation and maintenance, insertion of peroxisomal membrane proteins, compartmentalization of peroxisomal matrix proteins and selective degradation of peroxisomes via pexophagy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy
  • Extracellular Matrix Proteins / metabolism
  • Humans
  • Intracellular Membranes / metabolism*
  • Membrane Proteins / metabolism*
  • Peroxisomes / metabolism*
  • Protein Sorting Signals
  • Protein Transport
  • Signal Transduction*
  • Ubiquitin / metabolism

Substances

  • Extracellular Matrix Proteins
  • Membrane Proteins
  • Protein Sorting Signals
  • Ubiquitin
  • peroxisomal targeting sequence receptor