Commentary: Oncologic drugs in patients with organ dysfunction: a summary

Oncologist. 2007 Sep;12(9):1070-83. doi: 10.1634/theoncologist.12-9-1070.


There are few prospective data regarding the pharmacokinetics and clinical toxicity of commonly used chemotherapeutics in cancer patients with organ dysfunction. Although increasing numbers of studies are investigating newer chemotherapeutics in patients with liver or kidney dysfunction, most guidelines for dosing, especially for established agents, remain empiric. This review describes the available data (both prospective and case study) evaluating the impact of renal and hepatic dysfunction on toxicity and dosing of commonly used chemotherapeutics and provides a practical summary for their use in this setting.

Publication types

  • Review

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Case-Control Studies
  • Humans
  • Kidney / drug effects
  • Kidney Diseases / physiopathology*
  • Liver / drug effects
  • Liver Diseases / physiopathology*
  • Prospective Studies
  • Topoisomerase Inhibitors


  • Antibiotics, Antineoplastic
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Topoisomerase Inhibitors