The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon

J Nat Prod. 1991 Jul-Aug;54(4):1077-81. doi: 10.1021/np50076a024.

Abstract

The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Crystallization
  • Drug Screening Assays, Antitumor
  • Humans
  • Leukemia P388 / drug therapy
  • Molecular Structure
  • Plants, Medicinal*
  • Pyrones / chemistry
  • Pyrones / isolation & purification
  • Pyrones / pharmacology*
  • Styrenes / chemistry
  • Styrenes / isolation & purification
  • Styrenes / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Pyrones
  • Styrenes
  • goniodiol-7-monoacetate