Abstract
Advanced small cell carcinoma of the ovary (FIGO stage III or IV) is a rare and usually lethal tumor seen in adolescents and young women. In pediatric patients with advanced disease, there have been only two case reports of successful therapy, we report a third patient, diagnosed at 17 years of age, with an abdominal mass and metastatic disease to regional and distant lymph nodes, who was successfully treated with surgery and intensive multi-agent chemotherapy. Imatinib, thalidomide, and celecoxib were also administered for up to 24 months following initial chemotherapy. She remains in remission 3 years from diagnosis.
(c) 2008 Wiley-Liss, Inc.
MeSH terms
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Benzamides
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Bleomycin / administration & dosage
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Carcinoma, Small Cell / drug therapy
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Carcinoma, Small Cell / surgery
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Carcinoma, Small Cell / therapy*
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Celecoxib
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Etoposide / administration & dosage
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Female
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Humans
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Imatinib Mesylate
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Lymph Nodes / pathology
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Lymphatic Metastasis
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / surgery
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Ovarian Neoplasms / therapy*
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Piperazines / administration & dosage
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Pyrazoles / administration & dosage
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Pyrimidines / administration & dosage
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Sulfonamides / administration & dosage
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Thalidomide / administration & dosage
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Vinblastine / administration & dosage
Substances
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Benzamides
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Piperazines
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Pyrazoles
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Pyrimidines
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Sulfonamides
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Bleomycin
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Thalidomide
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Vinblastine
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Etoposide
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Doxorubicin
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Imatinib Mesylate
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Cyclophosphamide
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Celecoxib