Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia-reperfusion injury

Expert Opin Biol Ther. 2007 Oct;7(10):1575-82. doi: 10.1517/14712598.7.10.1575.


Recent studies showed that innate autoimmunity is an early mechanism for ischemia-reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity*
  • Complement Activation
  • Humans
  • Immunity, Innate*
  • Immunoglobulin M / blood*
  • Immunotherapy / methods*
  • Reperfusion Injury / immunology*
  • Reperfusion Injury / therapy


  • Immunoglobulin M