Incidence of endophthalmitis after 20- and 25-gauge vitrectomy

Ophthalmology. 2007 Dec;114(12):2133-7. doi: 10.1016/j.ophtha.2007.08.009. Epub 2007 Oct 4.


Purpose: To assess the incidence rate of endophthalmitis after 25-gauge pars plana vitrectomy and to compare it with the endophthalmitis rate after 20-gauge pars plana vitrectomy.

Design: Retrospective, interventional, comparative cohort study.

Participants: Eight thousand six hundred one consecutive pars plana vitrectomy surgery patients.

Methods: Surgeries performed at a single institution between January 1, 2004, and September 1, 2006, were reviewed.

Main outcome measures: Incidence of postvitrectomy endophthalmitis.

Results: Endophthalmitis developed in 1 of 5498 eyes after 20-gauge vitrectomy (0.018%) and in 7 of 3103 eyes after 25-gauge vitrectomy cases (0.23%; P = 0.004). Median final visual acuity was counting fingers or hand movements (range, 20/50-no light perception), with comparable results between 20-gauge and 25-gauge endophthalmitis cases.

Conclusions: The visual outcomes of vitrectomy-associated endophthalmitis, for both 20-gauge and 25-gauge vitrectomy, is poor. In this study population, 25-gauge vitrectomy had a statistically significant 12-fold higher incidence of endophthalmitis compared with 20-gauge vitrectomy.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Endophthalmitis / diagnosis
  • Endophthalmitis / epidemiology
  • Endophthalmitis / etiology*
  • Epiretinal Membrane / surgery
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Minimally Invasive Surgical Procedures / adverse effects*
  • Minimally Invasive Surgical Procedures / statistics & numerical data
  • Postoperative Complications*
  • Retrospective Studies
  • Risk Factors
  • Suture Techniques / adverse effects*
  • Suture Techniques / statistics & numerical data
  • Visual Acuity
  • Vitrectomy / adverse effects*
  • Vitrectomy / statistics & numerical data
  • Vitreous Hemorrhage / surgery