Orthopedic involvement in antiphospholipid syndrome

Clin Rev Allergy Immunol. 2007 Apr;32(2):167-71. doi: 10.1007/s12016-007-0006-y.

Abstract

Antiphospholipid syndrome (APS) is a common autoimmune disease, manifested by vascular thrombosis and fetal loss in the presence of antiphospholipid antibodies. Orthopedic involvement is a relatively novel and under-recognized feature of APS. In this article we review the association of primary, secondary, and catastrophic APS with diverse orthopedic conditions, including osteonecrosis in adult and pediatric patients, bone marrow necrosis, nontraumatic fractures, and some other disorders.

Publication types

  • Review

MeSH terms

  • Adult
  • Antibodies, Antiphospholipid*
  • Antiphospholipid Syndrome* / complications
  • Antiphospholipid Syndrome* / immunology
  • Antiphospholipid Syndrome* / physiopathology
  • Bone Marrow / immunology
  • Bone Marrow / pathology
  • Bone and Bones / immunology
  • Bone and Bones / injuries
  • Bone and Bones / pathology
  • Child
  • Female
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / immunology*
  • Humans
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / physiopathology
  • Necrosis
  • Osteonecrosis / etiology
  • Osteonecrosis / immunology*
  • Pregnancy
  • Primary Myelofibrosis / etiology
  • Primary Myelofibrosis / immunology

Substances

  • Antibodies, Antiphospholipid