Vaginal bleeding with multicystic ovaries and a pituitary mass in a child with severe hypothyroidism

Mymensingh Med J. 2007 Jul;16(2 Suppl):S60-62.


A seven year and ten months old girl presented with cyclic vaginal bleeding and a huge abdominopelvic mass. She had clinical features of hypothyroidism. The investigation results were consistent with the diagnosis of primary hypothyroidism with precocious puberty. She also had bilaterally enlarged cystic ovaries on CT scan of abdomen and CT scan of brain showed pituitary macroadenoma. After starting treatment with thyroxine, patient became euthyroid and her general condition improved. Treatment with thyroxine alone halted the cyclic vaginal bleeding, led to rapid resolution of the ovarian cysts and regression of the pituitary mass.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Female
  • Humans
  • Hypothyroidism / complications*
  • Hypothyroidism / physiopathology
  • Metrorrhagia / diagnosis*
  • Metrorrhagia / etiology
  • Pituitary Neoplasms / complications*
  • Pituitary Neoplasms / pathology
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / diagnosis*
  • Puberty, Precocious / etiology*
  • Risk Factors
  • Thyroxine / therapeutic use


  • Thyroxine