Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human

Neurosci Lett. 1991 Sep 30;131(1):66-70. doi: 10.1016/0304-3940(91)90338-t.

Abstract

The cellular localization of a dopamine- and cAMP-regulated phosphoprotein of Mr 32,000 (DARPP-32) was investigated in cat, monkey and human retina by immunohistochemistry. In cat, DARPP-32-immunoreactive cell bodies identified as Müller cells were demonstrated in the inner nuclear layer (INL) with processes closely surrounding the cell soma of photoreceptors in the outer nuclear layer. Some DARPP-32-IR cells were also seen in the nerve fiber layer (NFL) sending processes to the inner plexiform layer. In monkey and human retina, DARPP-32-IR cell bodies were also demonstrated in the INL, with few cells located in the NFL.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Cats
  • Dopamine and cAMP-Regulated Phosphoprotein 32
  • Fluorescent Antibody Technique
  • Humans
  • Macaca fascicularis
  • Nerve Tissue Proteins / analysis*
  • Phosphoproteins / analysis
  • Photoreceptor Cells / cytology
  • Retina / cytology*
  • Retina / pathology
  • Species Specificity

Substances

  • Antibodies, Monoclonal
  • Dopamine and cAMP-Regulated Phosphoprotein 32
  • Nerve Tissue Proteins
  • Phosphoproteins