Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways

Curr Opin Struct Biol. 2007 Dec;17(6):726-35. doi: 10.1016/j.sbi.2007.08.018. Epub 2007 Oct 4.


Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Models, Molecular
  • Protein Conformation
  • Ubiquitin / chemistry
  • Ubiquitin / metabolism*


  • Ubiquitin