Abstract
Trivalent inactivated split influenza virus vaccine has been used for more than 35 years, and is currently licensed in over 100 countries. To determine vaccine-preventable influenza burden in different populations and geographic regions, we reviewed studies of vaccine effectiveness against non-specific outcomes such as upper respiratory infection, hospitalization, and death in addition to confirmed microbiologically confirmed influenza. The vaccine-preventable disease incidence was high in most studies, regardless of the outcome or population evaluated. This indicates that routine influenza vaccination can improve overall population health under a broad range of circumstances.
MeSH terms
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Antibodies, Viral / biosynthesis
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Antibodies, Viral / immunology
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Clinical Trials as Topic
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Cost of Illness*
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Humans
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Immunization Programs
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Influenza Vaccines / administration & dosage
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Influenza Vaccines / economics*
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Influenza Vaccines / immunology
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Influenza, Human / economics*
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Influenza, Human / prevention & control
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Orthomyxoviridae / immunology
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Orthomyxoviridae Infections / economics*
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Orthomyxoviridae Infections / immunology
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Orthomyxoviridae Infections / prevention & control
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Orthomyxoviridae Infections / virology
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Vaccination
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Vaccines, Inactivated / administration & dosage
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Vaccines, Inactivated / economics*
Substances
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Antibodies, Viral
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Influenza Vaccines
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Vaccines, Inactivated
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vaxigrip