Bare rudiments of notch signaling: how receptor levels are regulated

Trends Biochem Sci. 2007 Oct;32(10):477-85. doi: 10.1016/j.tibs.2007.09.002.


The Notch signaling pathway, a prototype for high-fidelity intercellular signaling mechanisms, regulates cell fate and other fundamental processes. Notch receptors are activated by transmembrane ligands present on neighboring cells through ligand-dependent proteolysis. This liberates the receptor intracellular domain, creating a transcriptional coactivator. Although tremendous progress towards elucidating the Notch activation mechanism and Notch-dependent processes has been reported, perhaps the most fundamental issue of Notch signaling is still poorly understood -- how cell-type-specific Notch-receptor expression patterns are established and regulated. This is especially true for the four mammalian Notch receptors (Notch1-4), which exhibit unique and overlapping expression patterns. However, recent studies have demonstrated the transcriptional control of Notch receptor levels as an essential determinant of Notch signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Intercellular Signaling Peptides and Proteins / chemistry
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Ligands
  • Mammals
  • Molecular Sequence Data
  • Peptide Hydrolases / metabolism
  • Protein Binding
  • Receptors, Notch / chemistry
  • Receptors, Notch / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction*


  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Receptors, Notch
  • Peptide Hydrolases