Association between sleep duration and hemoglobin A1c level

Sleep Med. 2008 Oct;9(7):745-52. doi: 10.1016/j.sleep.2007.07.017. Epub 2007 Oct 24.


Objective: The association between sleep habits and hemoglobin A1c (HbA1c) level has not been sufficiently examined. In the present study of residents in a local community, the associations between sleep duration and HbA1c level were examined.

Methods: Self-administered questionnaires were mailed to 1062 residents in a rural community in Japan, and completed questionnaires were collected. At the time of collection, the fasting plasma glucose and Hb(1c levels were measured using peripheral blood samples. For the analyses, values that were considered to represent high levels were a fasting plasma glucose level of 126mg/dl and a HbA1c level of 6.5%. Logistic regression analyses were performed to examine the associations between sleep duration and high fasting plasma glucose or high HbA1c levels.

Results: The prevalence of high fasting plasma glucose and high HbA1c levels was significantly high (p<0.01) in subjects with a short or a long sleep duration. Logistic regression analyses demonstrated a significant association between high HbA1c level and sleep duration. The adjusted odds ratios for a high HbA1c level showed high values with regard to both short and long sleep durations.

Conclusions: HbA1c level showed a U-shaped association with sleep duration. These results suggest that there may be an appropriate range of sleep duration in individuals with glucose tolerance disorders. It is expected that the present findings will contribute to the treatment and prevention of diabetes mellitus.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Blood Glucose / metabolism
  • Disorders of Excessive Somnolence / blood
  • Female
  • Glycated Hemoglobin / metabolism*
  • Health Surveys
  • Humans
  • Japan
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio
  • Reference Values
  • Sex Factors
  • Sleep / physiology*
  • Sleep Initiation and Maintenance Disorders / blood
  • Surveys and Questionnaires
  • Young Adult


  • Blood Glucose
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human