Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii

J Nat Prod. 2007 Oct;70(10):1565-9. doi: 10.1021/np0702133. Epub 2007 Oct 9.

Abstract

From the petroleum ether extract of the root bark of Cussonia zimmermannii four polyacetylenes, 1- 4, were isolated, three of which ( 1- 3) were active against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium falciparum, and Leishmania donovani.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / isolation & purification*
  • Antiprotozoal Agents / pharmacology*
  • Araliaceae / chemistry*
  • Leishmania donovani / drug effects
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects
  • Polyynes / chemistry
  • Polyynes / isolation & purification*
  • Polyynes / pharmacology*
  • Tanzania
  • Trypanosoma brucei rhodesiense / drug effects

Substances

  • Antiprotozoal Agents
  • Polyynes