Objective: To investigate the correlation between adiponectin and metabolic risk factors of coronary heart disease in non-diabetic male patients.
Methods: 215 non-diabetic males aged (59 +/- 9) underwent coronary angiography (CAG) and then divided into coronary heart disease group (n = 127) and control group (n = 88) according to the CAG results. The anthroposomatologic parameters were measured. Blood sugar and lipids were examined. Adiponectin levels was detected with radioimmunoassay.
Results: The mean adiponectin level of the coronary heart disease group was 7.9 (5.7 - 11.6) mg/L, significantly lower than that of the control group [10.0 (7.0 - 13.5) mg/L, P = 0.014]. The adiponectin level of females was lower than those of the males, no matter whether with coronary heart disease. Partial correlation analysis showed that the adiponectin level was negatively correlated with the serum triglyceride, total cholesterol, post-challenge glucose level and body mass index (r = -0.250, -0.169, -0.167, -0.246, and -0.198, all P < 0.05), and positively correlated with HDL-C (r = 0.201, P = 0.001) after the age factor was controlled. Logistic multivariable stepwise regression analysis demonstrated levels of triglyceride and adiponectin independently associated with the presence of coronary heart disease (OR = 2.277 and 0.533 respectively).
Conclusion: Adiponectin is influenced by metabolic disorders. Higher adiponectin level is a protective factor of coronary heart disease.