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Review
. 2007 Oct 13;335(7623):755.
doi: 10.1136/bmj.39350.500428.47. Epub 2007 Oct 8.

Dietary Antioxidants and Primary Prevention of Age Related Macular Degeneration: Systematic Review and Meta-Analysis

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Free PMC article
Review

Dietary Antioxidants and Primary Prevention of Age Related Macular Degeneration: Systematic Review and Meta-Analysis

Elaine W-T Chong et al. BMJ. .
Free PMC article

Abstract

Objective: To evaluate the effectiveness of dietary antioxidants in the primary prevention of age related macular degeneration (AMD).

Design: Systematic review and meta-analysis.

Data sources: Search of seven databases without limits on year or language of publication, and retrieval of references in pertinent reviews and articles.

Methods: Two reviewers independently searched the databases and selected the studies, using standardised criteria. Randomised clinical trials and prospective cohort studies were included. Of the 4192 abstracts initially identified, 12 studies (nine prospective cohort studies and three randomised clinical trials) met the selection criteria and were included. Data extraction and study quality evaluation were independently reviewed, using standardised criteria. Results were pooled quantitatively using meta-analytic methods.

Results: The nine prospective cohort studies included 149 203 people, with 1878 incident cases of early AMD. The antioxidants investigated differed across studies, and not all studies contributed to the meta-analysis of each antioxidant. Pooled results from prospective cohort studies indicated that vitamin A, vitamin C, vitamin E, zinc, lutein, zeaxanthin, alpha carotene, beta carotene, beta cryptoxanthin, and lycopene have little or no effect in the primary prevention of early AMD. The three randomised clinical trials did not show that antioxidant supplements prevented early AMD.

Conclusions: There is insufficient evidence to support the role of dietary antioxidants, including the use of dietary antioxidant supplements, for the primary prevention of early AMD.

Conflict of interest statement

Competing interests: None declared.

Figures

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Fig 1 Flow chart of study selection process
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Fig 2 Pooled odds ratio for early AMD (highest v lowest dietary intake categories of vitamins and zinc)
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Fig 3 Pooled odds ratio for early AMD (highest v lowest dietary intake categories of carotenoids)
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Fig 4 Funnel plot of the odds ratio (for highest versus lowest intake categories) versus the standard error of the log odds ratio for studies evaluating lutein and zeaxanthin. Dotted line crosses the x axis at the estimate of the pooled odds ratio for early AMD

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