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. 2007 Sep;30(8):653-8.
doi: 10.1007/BF03347445.

Low 25-hydroxyvitamin D Concentrations in Obese Women: Their Clinical Significance and Relationship With Anthropometric and Body Composition Variables

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Low 25-hydroxyvitamin D Concentrations in Obese Women: Their Clinical Significance and Relationship With Anthropometric and Body Composition Variables

N Vilarrasa et al. J Endocrinol Invest. .

Abstract

Obesity is associated with low concentrations of 25-hydroxyvitamin D [25(OH) D]. However, conflicting results have been found regarding the relationship of 25(OH) D with anthropometric and adiposity parameters. The aim of our study was to analyze the association between 25(OH) D and body fat (BF) in a homogeneous cohort of non-obese, obese, and morbidly obese Caucasian women. The study was performed in L'Hospitalet de Llobregat, a city adjacent to Barcelona with a latitude of 41 degrees, 22 minutes, and 5 seconds north.

Materials and methods: Plasma concentrations of 25(OH) D were determined and body composition was evaluated by bioelectrical impedance in a group of 43 women with morbid obesity, 28 non-morbidly obese, and 50 non-obese women matched for age.

Results: Morbidly obese women showed lower 25(OH) D concentrations compared to non-morbidly and non-obese women (37.9+/-16 vs 40.2+/-13 vs 56.7+/-21 nmol/l, p=0.001). Fifty-one percent of morbidly obese women had vitamin D deficiency [25(OH) D<38 nmol/l] compared to 22% of non-obese patients, (p=0.004). In the bivariate correlation analysis 25(OH) D was inversely associated with weight (r=-0.41, p=0.001), body mass index (BMI) (r=-0.432, p=0.001), waist to hip ratio (WHR)(r=-0.40, p=0.001), BF (r=-0.53, p=0001), fat mass (r=-0.44, p=0.0001), fat-free mass (r=-0.35, p=0.001). In the multivariate general linear model analysis, 25(OH) D was associated with season of examination (p=0.001) and was negatively associated with BF (beta=-0.75, p=0.001), after adjusting for age, BMI, and WHR.

Conclusions: 25(OH) D concentrations are associated with body composition variables especially by BF, independently of seasonal variability. Therefore, body adiposity should be considered when assessing vitamin D requirements in obese patients.

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References

    1. Am J Clin Nutr. 2002 Jul;76(1):187-92 - PubMed
    1. Horm Metab Res. 2004 Jan;36(1):48-53 - PubMed
    1. Endocr Rev. 2001 Aug;22(4):477-501 - PubMed
    1. J Clin Invest. 1985 Dec;76(6):2403-12 - PubMed
    1. J Clin Endocrinol Metab. 2003 Jan;88(1):157-61 - PubMed

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