Reverse high blood pressure is new entity recently described. Our study shows that as well as our sister is not a boy, the diastolic value of blood pressure can clumber up the systolic level when the systolic value become too low to be more high than the diastolic one. This phenomenon is secondary to an excess plasma N concentration secondary to the cleavage of Na molecule in two parts in the helicoidal tubular lumen of the kidney, followed by N reabsorption and A urinary excretion. Our results provide evidence about an immunological mechanism which support the utility of plasma exchanges.