Twist expression in patients with cervical cancer is associated with poor disease outcome

Ann Oncol. 2008 Jan;19(1):81-5. doi: 10.1093/annonc/mdm344. Epub 2007 Oct 8.


Background: Twist, a basic helix--loop-helix transcription factor, has been reported to be associated with the development and progression of human cancer. We examined the distribution and expression of Twist in cervical cancer to examine its clinical significance.

Patients and methods: We examined the distribution and expression of Twist in 101 cervical cancer specimens and determined the association between their expression and the clinico-pathological features observed, including patient outcome.

Results: Of the 101 specimens, 55 cases were negative for Twist immuno-expression, whereas 46 were positive. When categorized into negative versus positive expression, Twist was not associated with any of the clinico-pathological parameters examined. Positive Twist expression significantly predicted poorer overall survival (OS) and progression-free survival (PFS) when compared with negative expression (P < 0.01). In the multivariate analyses, positive Twist expression was an independent prognostic factor for OS (P < 0.05).

Conclusions: Our data imply that positive Twist expression seems to be a useful marker in patients with cervical cancer likely to have an unfavorable clinical outcome.

MeSH terms

  • Adenocarcinoma / chemistry*
  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Carcinoma, Squamous Cell / chemistry*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / surgery
  • Cell Membrane / chemistry
  • Cell Transdifferentiation / genetics
  • Cytoplasm / chemistry
  • Disease-Free Survival
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Middle Aged
  • Neoplasm Proteins / analysis*
  • Nuclear Proteins / analysis*
  • Prognosis
  • Proportional Hazards Models
  • Radiation Tolerance / genetics
  • Twist-Related Protein 1 / analysis*
  • Uterine Cervical Neoplasms / chemistry*
  • Uterine Cervical Neoplasms / mortality
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / surgery


  • Neoplasm Proteins
  • Nuclear Proteins
  • TWIST1 protein, human
  • Twist-Related Protein 1