The association of opium with coronary artery disease

Eur J Cardiovasc Prev Rehabil. 2007 Oct;14(5):715-7. doi: 10.1097/HJR.0b013e328045c4e9.


Background: The effects of opium consumption on coronary artery disease are still unknown.

Methods: A cross-sectional study was conducted on 2405 patients admitted to the Angiographic Ward at Tehran Heart Center from 7 May 2005 to 13 August 2005.

Results: After adjusting for conventional cardiovascular risk factors, opium consumption was a significant risk factor for coronary artery disease (P=0.01 and odds ratio=1.8). Moreover, the amount of opium consumption was associated significantly with the severity of coronary atherosclerosis, as measured by clinical vessel score (r=0.2, P=0.002).

Conclusions: To our knowledge, this is the first time that the adverse effects of opium consumption on coronary arteries was defined.

MeSH terms

  • Aged
  • Coronary Disease / chemically induced*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Opium / adverse effects*
  • Risk Factors
  • Smoking / adverse effects
  • Substance-Related Disorders


  • Opium