[External respiration function and quality of life in patients with bronchial asthma in correction of selenium deficiency]

Ter Arkh. 2007;79(8):38-41.
[Article in Russian]

Abstract

Aim: To examine the effect of selenium (Se) adjuvant therapy on external respiration function (ERF) and quality of life (QOL) in bronchial asthma (BA) patients.

Material and methods: 26 patients with BA received standard therapy and adjuvant 200 mcg/day selenium (SelenoPRECISE, PharmaNord, Denmark) for 16 weeks. ERF was estimated by FEV1 and FVC, QOF--by the response to Juniper Adult Asthma Quality of life Short Questionnaire (AQLQ-S) at initiation and end of the study. Difference with the baseline was assessed using Paired Samples T-Test, SPSS 14.0.

Results: Paired-samples T-test showed that FVC increased significantly from 76.5 +/- 23.8% to 81.8 +/- 23.2% (p = 0.015). FEV1 showed a significant increase from 62.3 +/- 29.6% to 67.7 +/- 28.1% (p = 0.018). Total AQLQ score elevated from 3.25 to 4.71 (p = 0.01).

Conclusion: Correction of Se deficiency in BA patients on standard therapy improves ERF and BA-related QOL. Mechanisms of a protective Se action are involved in antioxidant defense by means of Se participation in enzymatic detoxication of peroxides and a stabilizing effect on biomembranes.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Asthma / complications
  • Asthma / physiopathology*
  • Asthma / psychology
  • Deficiency Diseases / blood
  • Deficiency Diseases / complications
  • Deficiency Diseases / drug therapy
  • Female
  • Follow-Up Studies
  • Forced Expiratory Flow Rates / physiology*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Selenium / blood
  • Selenium / deficiency*
  • Selenium Compounds / therapeutic use*
  • Treatment Outcome
  • Vital Capacity / physiology*

Substances

  • Selenium Compounds
  • Selenium