Tris buffer (THAM). An appraisal of its physiologic effects and clinical usefulness

N Engl J Med. 1966 Apr 7;274(14):782-7. doi: 10.1056/NEJM196604072741407.


It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental, or clinical, to support the view that Tris has a significant therapeutic role. Some possible exceptions to this general conclusion are considered.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Acidosis / drug therapy*
  • Acidosis, Respiratory / drug therapy
  • Acids / poisoning*
  • Blood Preservation
  • Buffers*
  • Citric Acid
  • Glucose / analogs & derivatives
  • Humans
  • Poisoning / drug therapy
  • Tromethamine / pharmacology
  • Tromethamine / therapeutic use*


  • Acids
  • Buffers
  • Tromethamine
  • acid citrate dextrose
  • Citric Acid
  • Glucose