Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Matthew E Merritt; Crystal Harrison; Zoltan Kovacs; Preeti Kshirsagar; Craig R Malloy; A Dean Sherry

doi:10.1021/ja075768z

Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

J Am Chem Soc. 2007 Oct 31;129(43):12942-3. doi: 10.1021/ja075768z. Epub 2007 Oct 10.

Authors

Matthew E Merritt¹, Crystal Harrison, Zoltan Kovacs, Preeti Kshirsagar, Craig R Malloy, A Dean Sherry

Affiliation

¹ Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8568, USA.

Abstract

Hyperpolarization of ⁸⁹YCl₃ and three ⁸⁹Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T₁’s of ⁸⁹Y make its application as an MR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of ⁸⁹Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biology
Ions / chemistry
Magnetic Resonance Spectroscopy / methods*
Yttrium / chemistry*

Substances

Ions
Yttrium

Abstract

Publication types

MeSH terms

Substances

Grants and funding