Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study

Nutr Cancer. 2007;59(1):54-61. doi: 10.1080/01635580701390223.


Epidemiological studies and laboratory data suggest that vitamin D may protect against the development of cancer, including breast cancer. Vitamin D supply affects the bioavailability of dietary calcium, which might also have anticarcinogenic effects. However, few studies considered them jointly. We used a population-based case-control study in Germany to examine the independent and joint effects of dietary vitamin D and calcium on premenopausal breast cancer risk. Dietary information was assessed using a validated food frequency questionnaire from 278 premenopausal cases and 666 age-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariate models adjusting vitamin D models for calcium intake and vice versa. Breast cancer risk was significantly inversely associated with vitamin D intake. The OR and 95% CI for the highest intake category (> or = 5 microg/day) was 0.50 (95% CI = 0.26-0.96) compared with the lowest (< 2 microg/day; P(trend) = 0.02). Dietary calcium intake was not associated with breast cancer (OR = 0.73, 95% CI = 0.41-1.29) for the highest (> or = 1,300 mg/day) versus the lowest category (< 700 mg/day), P(trend) = 0.29). No statistically significant interaction between the 2 nutrients was observed. Our data support a protective effect of dietary vitamin D on premenopausal breast cancer risk independent of dietary calcium intake.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / etiology
  • Breast Neoplasms / prevention & control
  • Calcium, Dietary / administration & dosage*
  • Calcium, Dietary / pharmacokinetics
  • Case-Control Studies
  • Confidence Intervals
  • Diet*
  • Female
  • Germany / epidemiology
  • Humans
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Premenopause
  • Risk Factors
  • Surveys and Questionnaires
  • Vitamin D / administration & dosage*
  • Vitamin D / pharmacology


  • Calcium, Dietary
  • Vitamin D