[Vitamin D and calcium metabolism in relation to different levels of vitamins B6 and D]

Vopr Pitan. 1991 Jul-Aug:(4):56-9.
[Article in Russian]


The influence of vitamin B6 deficiency on some vitamin D-dependent processes was studied in animals. The following parameters changing in relation to the level of vitamin D providing were investigated: activity of alkaline phosphatase in the serum and small intestine mucosa, the levels of Ca, P and parathormone, concentration of vitamin D metabolites and enzyme activity; and only 25-hydroxyvitamin D (25-OVD) concentration in the blood serum, under conditions of combined vitamin B6 and D deficiency was significantly lower as compared to cases with vitamin D deficiency alone. In the presence of vitamin B6 deficiency recovery of 25-OVD level in the blood serum, after vitamin D administration to the animals, had a tendency to delay as compared to that in the animals provided with vitamin B6. Vitamin B6 deficiency produced similar effect on 25-OVD 1-hydroxylase activity. The data obtained have evidenced a possibility of vitamin B6 influence on vitamin D metabolism.

Publication types

  • English Abstract

MeSH terms

  • Alkaline Phosphatase / metabolism
  • Animals
  • Calcium / metabolism*
  • Hydroxycholecalciferols / metabolism
  • Male
  • Parathyroid Hormone / metabolism
  • Phosphorus / metabolism
  • Rats
  • Rats, Inbred Strains
  • Vitamin B 6 Deficiency / metabolism*
  • Vitamin D Deficiency / metabolism*


  • Hydroxycholecalciferols
  • Parathyroid Hormone
  • Phosphorus
  • Alkaline Phosphatase
  • Calcium