No potassium, no acid: K+ channels and gastric acid secretion

Physiology (Bethesda). 2007 Oct;22:335-41. doi: 10.1152/physiol.00016.2007.


The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gastric Acid / metabolism*
  • H(+)-K(+)-Exchanging ATPase / metabolism
  • Humans
  • KCNQ1 Potassium Channel / metabolism
  • Parietal Cells, Gastric / cytology
  • Parietal Cells, Gastric / metabolism*
  • Parietal Cells, Gastric / pathology
  • Potassium / metabolism*
  • Potassium Channels, Inwardly Rectifying / metabolism
  • Potassium Channels, Voltage-Gated / antagonists & inhibitors
  • Potassium Channels, Voltage-Gated / metabolism*
  • Signal Transduction / physiology


  • KCNQ1 Potassium Channel
  • Potassium Channels, Inwardly Rectifying
  • Potassium Channels, Voltage-Gated
  • H(+)-K(+)-Exchanging ATPase
  • Potassium