Structure, Dynamics and Functions of Promyelocytic Leukaemia Nuclear Bodies

Nat Rev Mol Cell Biol. 2007 Dec;8(12):1006-16. doi: 10.1038/nrm2277.

Abstract

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Nucleus Structures / chemistry
  • Cell Nucleus Structures / physiology
  • Humans
  • Intranuclear Inclusion Bodies / chemistry*
  • Intranuclear Inclusion Bodies / physiology*
  • Neoplasm Proteins / metabolism
  • Nuclear Proteins / metabolism
  • Promyelocytic Leukemia Protein
  • Transcription Factors / metabolism
  • Tumor Suppressor Proteins / metabolism

Substances

  • Neoplasm Proteins
  • Nuclear Proteins
  • Promyelocytic Leukemia Protein
  • Transcription Factors
  • Tumor Suppressor Proteins
  • PML protein, human