Inbred mice and their hypbrids as an animal model for atherosclerosis research

Adv Exp Med Biol. 1976;67(00):313-327. doi: 10.1007/978-1-4614-4618-7_18.

Abstract

1. The inbred strain of mouse is a relatively inexpensive and easily controlled animal that produces consistent results within each of the P1, P2, F1, F2, B1 and B2 generations. 2. The mother and father exert an equal influence on the development of fatty deposits in the aortic sinus wall and on serum total cholesterol levels. 3. Different strains of inbred mice react to the high-fat, high-cholesterol diet in different ways. 4. The control mice of the CBA/J (P2) strain had significantly lower values of serum total cholesterol and size of the largest lesion at some weeks than the control mice of the C57BR/cdJ and F1, F2, B1 and B2 generations. 5. The experiments indicate a multifactorial (polygenic) system of inheritance.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Aorta / pathology
  • Arteriosclerosis / genetics*
  • Arteriosclerosis / pathology
  • Cholesterol / blood
  • Diet, Atherogenic
  • Disease Models, Animal*
  • Genes
  • Hybridization, Genetic
  • Inclusion Bodies / ultrastructure
  • Lipids / analysis
  • Male
  • Mice
  • Mice, Inbred Strains / anatomy & histology*

Substances

  • Lipids
  • Cholesterol