Optic nerve manifestations of human congenital cytomegalovirus infection

Am J Ophthalmol. 1976 May;81(5):661-5. doi: 10.1016/0002-9394(76)90134-3.


A Latin American male and a white female infant who had a cytomegalovirus infection on the first day of life had unilateral optic nerve hypoplasia. A white male infant who had cytomegalovirus isolated at 5 weeks of age had a unilateral partial coloboma of the optic nerve. A 4-month-old black infant with cytomegalovirus infection diagnosed at 2 days of age had a unilateral complete coloboma of the optic nerve associated with microphthalmia. Optic nerve involvement was an important manifestation of this disease.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child, Preschool
  • Chorioretinitis / diagnostic imaging
  • Coloboma / diagnostic imaging
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / congenital
  • Eye Manifestations
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Ophthalmoscopy
  • Optic Neuritis / diagnostic imaging*
  • Radiography
  • Vision Disorders / diagnostic imaging