A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Planta Med. 2007 Oct;73(13):1412-5. doi: 10.1055/s-2007-990232. Epub 2007 Oct 11.

Abstract

Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line, Tumor / drug effects
  • Fermentation
  • Humans
  • Inhibitory Concentration 50
  • Mycelium
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Polyporales*
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology
  • Ubiquinone / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Ubiquinone
  • antroquinonol