Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

Nat Med. 2007 Nov;13(11):1359-62. doi: 10.1038/nm1653. Epub 2007 Oct 14.


A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / blood
  • Alzheimer Disease / classification*
  • Alzheimer Disease / diagnosis*
  • Biomarkers / blood
  • Cognition Disorders / blood
  • Cognition Disorders / classification
  • Cognition Disorders / diagnosis
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Phenotype
  • Predictive Value of Tests


  • Biomarkers
  • Intercellular Signaling Peptides and Proteins